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Author: Thomas Rubin
Aim 2: Differential regulation of abscission between germline stem cells and differentiating daughter cells.
We have found that AuroraB and CyclinB localize at the midbody, and that CycB/Cdk-1 promotes abscission, while AuroraB/Survivin inhibits it. Both complexes have other functions during the cell cycle, which are mainly the control of entry into M phase and the metaphase-anaphase transition. At these two stages, the regulation of AuroraB and Cdk-1 is well-described and a list of known regulators is available 12.
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Differential regulation of abscission between germline stem cells and differentiating daughter cells.
We have found that AuroraB and CyclinB localize at the midbody, and that CycB/Cdk-1 promotes abscission, while AuroraB/Survivin inhibits it. Both complexes have other functions during the cell cycle, which are mainly the control of entry into M phase and the metaphase-anaphase transition. At these two stages, the regulation of AuroraB and Cdk-1 is well-described and a list of known regulators is available 12.
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Aim 2: Differential regulation of abscission between germline stem cells and differentiating daughter cells.
We have found that AuroraB and CyclinB localize at the midbody, and that CycB/Cdk-1 promotes abscission, while AuroraB/Survivin inhibits it. Both complexes have other functions during the cell cycle, which are mainly the control of entry into M phase and the metaphase-anaphase transition. At these two stages, the regulation of AuroraB and Cdk-1 is well-described and a list of known regulators is available 12.
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Abcission
Aim 2: Differential regulation of abscission between germline stem cells and differentiating daughter cells.
We have found that AuroraB and CyclinB localize at the midbody, and that CycB/Cdk-1 promotes abscission, while AuroraB/Survivin inhibits it. Both complexes have other functions during the cell cycle, which are mainly the control of entry into M phase and the metaphase-anaphase transition. At these two stages, the regulation of AuroraB and Cdk-1 is well-described and a list of known regulators is available 12.
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